Hyperostosis frontalis interna (HFI) in the population of the Dnieper-Donets archaeological culture

Introduction. Hyperostosis frontalis interna (HFI) is a thickening of the frontal bone associated with metabolic and hormonal disorders. While prevalent among elderly women in modern populations, archaeological studies have documented male-dominated HFI cases in certain groups. This study examines the frequency of HFI in Mesolithic/Neolithic craniological series from the Dnieper region. Materials and methods. Eight craniological series (107 skulls) from the collections of the Research Institute and Museum of Anthropology, Lomonosov Moscow State University, were analyzed. The overall prevalence of HFI and its developmental stages (4-point scale) were assessed. Results and discussion. A high HFI frequency (20.6%) was identified in Mesolithic/Neolithic groups of the Dnieper region, suggesting a link to chronic metabolic stress during transitional periods. Notably, HFI types A, B, and C were equally represented (1:1:1 ratio), contrasting with typical patterns where type A dominates. Elevated frequencies of types B and C likely indicate metabolic/hormonal imbalances. Although no statistically significant sex or age differences were observed, a trend of increased HFI prevalence in older individuals aligns with prior research. Associations with periodontitis, trauma, and cribra orbitalia point to environmental stress influences. Conclusion. The identified HFI cases represent the earliest known instances in prehistoric Eastern Europe. Results underscore HFI’s role as a stress marker in transitional historical periods. © 2025. This work is licensed under a CC BY 4.0 license