E7386 Enhances Lenvatinib’s Antitumor Activity in Preclinical Models and Human Hepatocellular Carcinoma
E7386 sensitized tumors to lenvatinib, thereby enhancing survival in mice compared with either monotherapy. In patients, E7386 combined with lenvatinib promoted tumor shrinkage and, in parallel, activated ATF4 signaling.
Authors
- Agavni Mesropian (ORCID: https://orcid.org/0000-0002-0604-4755)
- Roger Esteban-Fabró (ORCID: https://orcid.org/0000-0002-8173-3323)
- Alka A. Potdar (ORCID: https://orcid.org/0000-0002-1877-0172)
- Jialing Shen
- Daniela Sia (ORCID: https://orcid.org/0000-0002-9000-611X)
- Marta Piqué‐Gili (ORCID: https://orcid.org/0000-0003-4873-7776)
- Albert Gris‐Oliver (ORCID: https://orcid.org/0000-0003-1802-9541)
- Masafumi Ikeda (ORCID: https://orcid.org/0000-0002-4050-2086)
- Jordi Abril‐Fornaguera (ORCID: https://orcid.org/0000-0002-5871-4052)
- Ugne Balaseviciute (ORCID: https://orcid.org/0000-0002-4256-4336)
- Masatoshi Kudo (ORCID: https://orcid.org/0000-0002-4102-3474)
- Roser Pinyol (ORCID: https://orcid.org/0000-0002-0288-6314)
- Katherine E. Lindblad (ORCID: https://orcid.org/0000-0001-6093-5578)
- Ana Hernández de Sande (ORCID: https://orcid.org/0009-0006-2154-9723)
- Judit Peix (ORCID: https://orcid.org/0000-0001-8203-7656)
- Josep Maria Llovet (ORCID: https://orcid.org/0000-0003-0547-2667)
- Ieva Keraite (ORCID: https://orcid.org/0000-0003-1974-9479)
- Ernesto Guccione (ORCID: https://orcid.org/0000-0001-7764-5307)
- Amaia Lujambio (ORCID: https://orcid.org/0000-0002-2798-1481)
- Elisa Fernández‐Martínez (ORCID: https://orcid.org/0009-0008-4390-5615)
- Marina Bárcena‐Varela (ORCID: https://orcid.org/0000-0001-7868-7939)
- Júlia Huguet‐Pradell (ORCID: https://orcid.org/0000-0003-1489-356X)
- Swan N. Thung (ORCID: https://orcid.org/0000-0003-4407-2295)
- Martí Torres-Marcén (ORCID: https://orcid.org/0009-0007-2564-9139)
- Takayuki Kimura (ORCID: https://orcid.org/0000-0003-2553-3076)
- David Camell-Raventos (ORCID: https://orcid.org/0009-0002-1591-7586)
Institutions
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Mount Sinai Hospital (US)
- Departament de Salut (ES)
- Institut d'Investigacions Biomèdiques de Barcelona (ES)
- Tisch Hospital (US)
- National Cancer Center Hospital East (JP)
- Eisai (United States) (US)
- Fundació Clínic per a la Recerca Biomèdica (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Eisai (Japan) (JP)
- Kindai University (JP)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-0725
- Citations
- 1
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Georgia Clinical and Translational Science Alliance
- Generalitat de Catalunya
- Eisai
- Ministerio de Ciencia e Innovación
- Universitat de Barcelona
- European Association for the Study of the Liver
- Societat Catalana de Digestologia
- National Institutes of Health
- Chugai Pharmaceutical
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- National Center for Advancing Translational Sciences