Spatial Profiling Identifies Tumor-Associated Stroma Enrichment and MIF as Potential Immunotherapy Targets in Primary Ewing Sarcomas
In addition to the immune recruitment role of tumor-associated stroma, our findings provide spatial insights into the TME of Ewing sarcoma and provide a rationale for the preclinical investigation of MIF as a potential target for Ewing sarcoma immunotherapy.
Authors
- Micha Sam Brickman Raredon (ORCID: https://orcid.org/0000-0003-1441-6122)
- Andrew E. Goodspeed (ORCID: https://orcid.org/0000-0001-7055-7128)
- Masanori Hayashi (ORCID: https://orcid.org/0000-0002-9508-0159)
- Christopher Kuo (ORCID: https://orcid.org/0000-0002-6222-147X)
- Nick Shillingford (ORCID: https://orcid.org/0000-0001-9636-9977)
- Mikako Warren (ORCID: https://orcid.org/0000-0002-1178-3835)
- James F. Amatruda (ORCID: https://orcid.org/0000-0002-9901-2137)
- Krinio Giannikou (ORCID: https://orcid.org/0000-0002-9633-3541)
- N.-K. Wang (ORCID: https://orcid.org/0009-0007-2670-7273)
Institutions
- University of Southern California (US)
- Children's Hospital of Los Angeles (US)
- Yale University (US)
- University of Colorado Cancer Center (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-0635
- Citations
- 1
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 0.80