Ketosis-Prone Diabetes in Severe Hypertriglyceridemia-Induced Pancreatitis: A Case Report

Diabetic ketoacidosis (DKA) is a serious acute complication commonly associated with type 1 diabetes mellitus (T1DM). It is characterized by elevated blood glucose levels, increased ketone production due to insufficient insulin, and metabolic acidosis. Acute pancreatitis (AP) is an inflammatory condition of the pancreas that can range from mild, self-limiting episodes to severe, life-threatening illness. The triad of DKA, hypertriglyceridemia, and AP presents a unique and challenging clinical scenario. This report describes the case of a 41-year-old female diagnosed with ketosis-prone diabetes and severe hypertriglyceridemia-induced pancreatitis. The case highlights several important considerations for clinicians and underscores the intricate interplay between metabolic disturbances, emphasizing the need for a comprehensive, multidisciplinary approach to management and treatment to address underlying causes and prevent future complications.

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Publication Details

Journal
Cureus
Published
2025-09-23
DOI
https://doi.org/10.7759/cureus.93035
Primary Topic
Pancreatitis Pathology and Treatment
Type
article
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0.00
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article

Ketosis-Prone Diabetes in Severe Hypertriglyceridemia-Induced Pancreatitis: A Case Report

Sheima M. Dahman, Abdullah Almutairi, Mushabab A Alshahrani, Saleh N Alkurini
Cureus
Pancreatitis Pathology and Treatment
article

Ketosis-Prone Diabetes in Severe Hypertriglyceridemia-Induced Pancreatitis: A Case Report

Sheima M. Dahman, Abdullah Almutairi, Mushabab A Alshahrani, Saleh N Alkurini
article en

Abstract

Diabetic ketoacidosis (DKA) is a serious acute complication commonly associated with type 1 diabetes mellitus (T1DM). It is characterized by elevated blood glucose levels, increased ketone production due to insufficient insulin, and metabolic acidosis. Acute pancreatitis (AP) is an inflammatory condition of the pancreas that can range from mild, self-limiting episodes to severe, life-threatening illness. The triad of DKA, hypertriglyceridemia, and AP presents a unique and challenging clinical scenario. This report describes the case of a 41-year-old female diagnosed with ketosis-prone diabetes and severe hypertriglyceridemia-induced pancreatitis. The case highlights several important considerations for clinicians and underscores the intricate interplay between metabolic disturbances, emphasizing the need for a comprehensive, multidisciplinary approach to management and treatment to address underlying causes and prevent future complications.

CureusVol. 17(9)
King Fahd Medical City (SA), Security Forces Hospital (SA), King Khalid University (SA)
Openalex Percentile: Top 59%
Pancreatitis Pathology and Treatment
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Ketosis-Prone Diabetes in Severe Hypertriglyceridemia-Induced Pancreatitis: A Case Report — Sheima M. Dahman, Abdullah Almutairi, et al. · Cureus (2025) | TGRS Research Map | TGRS