Obstetric aspects of metabolically associated steatotic liver disease

Аim - to review the current literature on the frequency, etiopathogenetic factors, diagnosis and treatment of metabolically associated steatotic liver disease (MASLD) in pregnant women to develop criteria for predicting complications of pregnancy and childbirth. The relevance of the problem of MASLD worldwide in the general population and in pregnant women is shown. Etiopathogenetic factors and risk factors that determine the occurrence of the disease are considered. The effectiveness of methods for diagnosing and treating pregnant women with MASLD is analyzed. Attention is focused on complications caused by MASLD during pregnancy for both the mother and the fetus. The impact of MASLD on the course of pregnancy and childbirth is considered, in particular, the risk of miscarriage, gestosis, premature birth, placental complications, fetal hypoxia, postpartum hemorrhage, and other obstetric problems. Conclusions. Metabolically associated steatotic liver disease in the modern world has a tendency to increase in the general population, therefore it is a high socio-economic burden and is a global health problem that needs to be addressed by both medical communities and politicians, especially in obstetric practice, because pregnancy against the background of MASLD is characterized by a high risk of complications of both pregnancy and childbirth, leading to impaired condition of mothers, newborns and subsequent development of children, which indicates the need to develop criteria for routine screening of this nosology before conception and during pregnancy to identify a high risk group for the development of MASLD, criteria for timely prediction of complications of pregnancy, childbirth and optimize the tactics of pregnancy, childbirth and the postpartum period, which will lead to a decrease in obstetric and perinatal complications. The authors declare no conflict of interest.