<b>Screening for Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients With Type 2 Diabetes: Are We Doing Enough?</b>

<p dir="ltr"><b>OBJECTIVE. </b>Patients with type 2 diabetes are at an elevated risk for metabolic dysfunction-associated steatotic liver disease and advanced liver fibrosis. Multiple professional societies recommend initiating screening with a fibrosis-4 (FIB-4) index score calculation. This study aimed to evaluate the frequency of laboratory assessments necessary for FIB-4 score calculation in patients with type 2 diabetes.</p><p dir="ltr"><b>RESEARCH DESIGN AND METHODS. </b>A retrospective analysis of de-identified electronic medical records from 337,094<b> </b>patients aged 40–75 years with type 2 diabetes was conducted to evaluate the completion rate of FIB-4 scoring and adherence to other recommended measurements and medications, including urinary albumin measurement and statin use.</p><p dir="ltr"><b>RESULTS. </b>Only 33% of patients with type 2 diabetes had all necessary components for FIB-4 score calculation, although this rate increased significantly over time (odds ratio 2.51, 95% CI 2.44–2.58) in the period from 2020 to April 2024 compared with 2010–2014. Urinary albumin measurements also increased but remained low at 13% during the period from 2020 to April 2024. Prescriptions for statin and newer antihyperglycemic medications significantly increased.</p><p dir="ltr"><b>CONCLUSION. </b>Our findings indicate that, although testing frequency for liver health in patients with type 2 diabetes is gradually increasing, substantial gaps in clinical practice persist.</p>

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Publication Details

Published
2025-09-23
DOI
https://doi.org/10.2337/figshare.29996575
Primary Topic
Liver Disease Diagnosis and Treatment
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article

Screening for Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients With Type 2 Diabetes: Are We Doing Enough?

Paul Y. Kwo, Gavin Hui, Sun H. Kim, Marcie Levine et al.
Liver Disease Diagnosis and Treatment
article

Screening for Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients With Type 2 Diabetes: Are We Doing Enough?

Paul Y. Kwo, Gavin Hui, Sun H. Kim, Marcie Levine, Michael L. Jackson, C. William Pike
article en

Abstract

<p dir="ltr"><b>OBJECTIVE. </b>Patients with type 2 diabetes are at an elevated risk for metabolic dysfunction-associated steatotic liver disease and advanced liver fibrosis. Multiple professional societies recommend initiating screening with a fibrosis-4 (FIB-4) index score calculation. This study aimed to evaluate the frequency of laboratory assessments necessary for FIB-4 score calculation in patients with type 2 diabetes.</p><p dir="ltr"><b>RESEARCH DESIGN AND METHODS. </b>A retrospective analysis of de-identified electronic medical records from 337,094<b> </b>patients aged 40–75 years with type 2 diabetes was conducted to evaluate the completion rate of FIB-4 scoring and adherence to other recommended measurements and medications, including urinary albumin measurement and statin use.</p><p dir="ltr"><b>RESULTS. </b>Only 33% of patients with type 2 diabetes had all necessary components for FIB-4 score calculation, although this rate increased significantly over time (odds ratio 2.51, 95% CI 2.44–2.58) in the period from 2020 to April 2024 compared with 2010–2014. Urinary albumin measurements also increased but remained low at 13% during the period from 2020 to April 2024. Prescriptions for statin and newer antihyperglycemic medications significantly increased.</p><p dir="ltr"><b>CONCLUSION. </b>Our findings indicate that, although testing frequency for liver health in patients with type 2 diabetes is gradually increasing, substantial gaps in clinical practice persist.</p>

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Liver Disease Diagnosis and Treatment
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<b>Screening for Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients With Type 2 Diabetes: Are We Doing Enough?</b> — Paul Y. Kwo, Gavin Hui, et al. · (2025) | TGRS Research Map | TGRS