Obesity Paradox and Lung Cancer Mortality: The Contributing Roles of Airflow Limitation and Pre–Chronic Obstructive Pulmonary Disease
We propose that the obesity paradox in high-risk ever-smokers who develop lung cancer results, in large part, from the stronger deleterious effect of airflow limitation on LC mortality, with a lesser effect associated with DM-pre-COPD, where each predominate at opposite ends of the BMI continuum.
Authors
- Robert P. Young (ORCID: https://orcid.org/0000-0002-0055-6450)
- Gerard A. Silvestri (ORCID: https://orcid.org/0000-0002-8464-2187)
- Zhitian Wang
- R.J. Scott
Institutions
- Medical University of South Carolina (US)
- University of Auckland (NZ)
Publication Details
- Journal
- Annals of the American Thoracic Society
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1513/annalsats.202505-499oc
- Citations
- 1
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52