Heavy ion radiation induces pyroptosis in skin keratinocytes through a mitogen-activated protein kinase signaling pathway
<sup>12</sup>C ion irradiation induced pyroptosis in human keratinocytes by a non-classical pathway via the activation of MAPK/NF-κB signaling pathway. The findings may be used to guide further research on targeted interventions to reduce skin damage and optimize treatment strategies in the future.
Authors
- Yan Du (ORCID: https://orcid.org/0000-0001-9931-4197)
- Yumeng Huang (ORCID: https://orcid.org/0009-0005-8240-8791)
- X. Wang (ORCID: https://orcid.org/0009-0006-6458-7033)
- Ye Zhao (ORCID: https://orcid.org/0000-0003-1384-6024)
- Li Zhu (ORCID: https://orcid.org/0000-0001-5249-6536)
- Zhiqiang Zhang (ORCID: https://orcid.org/0009-0005-5922-3385)
- Haoxiang Wang (ORCID: https://orcid.org/0009-0006-5395-7668)
- Guangming Zhou
Institutions
- Anhui Medical University (CN)
- Chinese Academy of Sciences (CN)
- Institute of Modern Physics (CN)
Publication Details
- Journal
- International Journal of Radiation Biology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1080/09553002.2025.2561813
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00