Safety of methylprednisolone irrigation during sialendoscopy: effects on the hypothalamic-pituitary-adrenal axis
Methylprednisolone irrigation during sialendoscopy caused biochemical HPA axis suppression in 37% of patients after 24 h. However, the procedure is considered safe, as there were no reported cases of clinical hypocortisolemia. The decrease in serum cortisol at 24 h was observed mainly after parotid gland irrigation. Minimal drug concentrations were found in the serum after 24 h.
Authors
- Angelos Chatziavramidis (ORCID: https://orcid.org/0000-0003-4921-5160)
- Vasileios Nikolaidis
- Dimitrios G. Goulis (ORCID: https://orcid.org/0000-0002-5005-1995)
- Konstantinos Markou (ORCID: https://orcid.org/0000-0001-9891-5185)
- Konstantinos Garefis (ORCID: https://orcid.org/0000-0003-3905-5650)
- Iordanis Konstantinidis (ORCID: https://orcid.org/0000-0002-9244-464X)
Institutions
- Aristotle University of Thessaloniki (GR)
- Papageorgiou General Hospital (GR)
Publication Details
- Journal
- European Archives of Oto-Rhino-Laryngology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1007/s00405-025-09678-1
- Primary Topic
- Salivary Gland Tumors Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hellenic Academic Libraries Link