EFFECT OF CLINICAL TREATMENTS FOR METABOLIC SYNDROME ON ALBUMINURIA: A SYSTEMATIC REVIEW AND META-ANALYSIS

Aims: The present study aimed to synthesize the literature on the efficacy of treatments with a positive impact on reducing albuminuria in adult patients with metabolic syndrome (MetS). Methods: The present study followed the Joanna Briggs Institute (JBI) methodology for systematic reviews and meta-analyses. The inclusion criteria were studies evaluating treatments in adult patients with MetS. Studies describing treatments in children, pregnant women, animals and patients with type 1 diabetes were excluded. The databases selected for the search strategy were Cochrane, Embase, Scopus, Medline/PubMed and Dart-E Europe ETheses, without language restrictions. Studies since 2009 were included due to the consensus definition of MetS. Study selection and evaluation and data collection were performed by two independent reviewers. The search strategy was performed in August and September 2021. Results: Twenty-one articles were included, which showed that lifestyle changes and bariatric surgery seemed to reduce albuminuria in patients with MetS. Only three articles were included in the meta-analysis. In this analysis, diet alone or together with physical exercise was effective for reducing albuminuria in patients with MetS. Conclusions: Diet alone or associated with physical exercise has an impact on decreasing albuminuria in patients with MetS.