Role of E2F1, taking account for the transcriptional activity of lncRNA HOTAIR, in vascular calcification via epigenetic silencing of KLF16/Klotho
HOTAIR, transcriptionally activated by E2F1, exerts a protective effect against vascular calcification by modulating KLF16/Klotho axis. This protective mechanism involves recruitment of KDM1A and EZH2. These findings provide potential new therapeutic targets for CKD treatment.
Authors
- Wei Tu (ORCID: https://orcid.org/0000-0002-0255-4037)
- Minzi Qiu
- Ben Ke (ORCID: https://orcid.org/0000-0002-4813-7108)
- Yanxia Chen (ORCID: https://orcid.org/0000-0002-1370-7422)
- Honghong Zou (ORCID: https://orcid.org/0009-0002-3172-2850)
- Yan Chen (ORCID: https://orcid.org/0000-0003-3808-1259)
Institutions
- Nanchang University (CN)
- Second Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Journal of Hypertension
- Published
- 2025-09-03
- DOI
- https://doi.org/10.1097/hjh.0000000000004104
- Citations
- 1
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.81