Terpenes as Naturally Occurring Stereochemical Templates: Conformationally Driven Discovery of Reactivity
Natural terpene-derived substrates have been used as stereochemical templates in the gold(I)-catalyzed cycloisomerization of aliphatic 1-bromoalkynes. The conformational restrictions imposed by these substrates have unlocked an unprecedented 5-<i>exo</i> cyclization mode in gold catalysis. This reactivity was extended to structurally simplified substrates.
Authors
- Rubén Miguélez
- Hannah Siera (ORCID: https://orcid.org/0000-0002-2259-9996)
- Isabel Merino
- Gebhard Haberhauer (ORCID: https://orcid.org/0000-0002-5427-7510)
- Johannes H. Schulte (ORCID: https://orcid.org/0000-0003-0671-1201)
- Pablo Barrio (ORCID: https://orcid.org/0000-0001-7101-4037)
- Omar Arto
Institutions
- Universidad de Oviedo (ES)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1021/acs.orglett.5c03431
- Citations
- 3
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 2.81