The impact of monocyte to HDL ratio and Prognostic Nutritional Index on survival in stage III colorectal cancer patients

Aims: This study explores how systemic inflammatory and nutritional indicators, specifically the monocyte-to-high-density lipoprotein ratio (MHR) and Prognostic Nutritional Index (PNI), influence clinical outcomes in stage III colorectal cancer (CRC) patients. Methods: A retrospective review of 109 individuals was conducted. ROC curve analysis was employed to determine the optimal cut-off values of MHR and PNI for predicting mortality. Survival outcomes, including overall survival (OS) and disease-free survival (DFS), were evaluated using Kaplan-Meier estimates and compared with log-rank tests. Cox regression was utilized to pinpoint factors independently associated with DFS. Results: The findings revealed significantly lower OS among patients not undergoing adjuvant chemotherapy (45.6 vs. 82.2 months; p=0.002). Additionally, diminished MHR (