Anti-inflammatory cytokine profile and Jarisch-Herxheimer reaction in Leptospirosis patients: A prospective case-series study in New Caledonia
This study confirms the stealth nature of leptospires, which induce a potent anti-inflammatory response rather than inflammation. It calls into question both the cytokine storm hypothesis, which is often cited in leptospirosis and the use of immunosuppressive drugs. The high incidence of JHR in New Caledonia suggests that the systematic use of ß-lactams as a first-line treatment should be reevaluated.
Authors
- Cyrille Goarant (ORCID: https://orcid.org/0000-0002-0690-9464)
- Damaris Ukeiwe
- Julien Colot (ORCID: https://orcid.org/0000-0001-6267-7920)
- J Lebon (ORCID: https://orcid.org/0000-0001-5824-6116)
- Franz Baur
- Catherine Werts (ORCID: https://orcid.org/0000-0003-3079-5476)
- Patrick Lefèvre
- Julie Cagliero (ORCID: https://orcid.org/0000-0002-8476-2680)
- Anne Loarec (ORCID: https://orcid.org/0000-0003-0877-2358)
- Sophie Tardieu (ORCID: https://orcid.org/0000-0002-1835-8153)
- E. Follenfant
- Cécile Cazorla
Institutions
- Pacific Community (NC)
- Institut Pasteur (FR)
- Centre Hospitalier Territorial de Nouvelle-Calédonie (NC)
- Institut Pasteur de Nouvelle Calédonie (NC)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1371/journal.pntd.0013189
- Primary Topic
- Leptospirosis research and findings
- Type
- article
- Field-Weighted Citation Impact
- 0.00