EML4−ALK Variant-Specific Genetic Interactions Shape Lung Tumorigenesis
EML4-ALK-driven lung cancer is treated as a uniform disease despite the presence of distinct fusion variants in patients. Our findings show that EML4-ALK variants are functionally distinct, which may have implications for the treatment of this cancer type and highlights the need to consider differences among variants of other oncogenic fusions.
Authors
- Laura Andrejka (ORCID: https://orcid.org/0000-0002-2202-5626)
- Min K. Tsai (ORCID: https://orcid.org/0000-0003-4732-4259)
- Smruthy Sivakumar (ORCID: https://orcid.org/0000-0001-7790-5615)
- Ethan Sokol (ORCID: https://orcid.org/0000-0002-5480-8473)
- Emily G. Shuldiner (ORCID: https://orcid.org/0000-0002-5018-0500)
- Karen Y. Shih (ORCID: https://orcid.org/0000-0001-7669-1643)
- Ilse Hofmann (ORCID: https://orcid.org/0000-0002-3586-5050)
- Christopher W. Murray (ORCID: https://orcid.org/0000-0001-7027-892X)
- Stewart J. Kim (ORCID: https://orcid.org/0000-0001-7196-0541)
- Rocı́o Sotillo (ORCID: https://orcid.org/0000-0002-0855-7917)
- Óscar González-Velasco (ORCID: https://orcid.org/0000-0002-5054-8635)
- Benedikt Brors (ORCID: https://orcid.org/0000-0001-5940-3101)
- Monte M. Winslow (ORCID: https://orcid.org/0000-0002-5730-9573)
- Saumya D. Sisoudiya (ORCID: https://orcid.org/0000-0001-7276-8084)
- Hongchen Cai (ORCID: https://orcid.org/0000-0002-5921-5773)
- Kálmán Somogyi (ORCID: https://orcid.org/0000-0001-8377-9766)
- Dmitri A. Petrov (ORCID: https://orcid.org/0000-0002-3664-9130)
- Alberto Diaz-Jimenez (ORCID: https://orcid.org/0009-0002-8311-2413)
- Filiz Akkas
- Mulham Najajreh (ORCID: https://orcid.org/0000-0002-3355-8866)
Institutions
- Salk Institute for Biological Studies (US)
- German Cancer Research Center (DE)
- Xiamen University (CN)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Boston Foundation (US)
- GlobalFoundries (United States) (US)
- Chan Zuckerberg Initiative (United States) (US)
- German Center for Lung Research (DE)
- Emergency Medicine Foundation (US)
- Stanford Medicine (US)
- Foundation Medicine (United States)
- Heidelberg University (US)
- Stanford University (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-1417
- Citations
- 3
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 4.56