Fixed-Dose Brexpiprazole and Sertraline Combination Therapy for the Treatment of Posttraumatic Stress Disorder
PTSD symptom improvement was similar with fixed-dose brexpiprazole+sertraline and sertraline+placebo; the primary endpoint was not met. This differs from 2 prior trials that showed greater efficacy for brexpiprazole+sertraline versus sertraline+placebo. No new safety signals were observed.
Authors
- Taisa Skubiak (ORCID: https://orcid.org/0009-0005-4396-2693)
- Klaus Groes Larsen (ORCID: https://orcid.org/0000-0002-5990-0113)
- Starla M. Weaver (ORCID: https://orcid.org/0000-0002-9559-8337)
- Lori L. Davis (ORCID: https://orcid.org/0000-0002-6098-5986)
- Nanco Hefting (ORCID: https://orcid.org/0000-0003-3310-3439)
- Daniel J. Lee (ORCID: https://orcid.org/0000-0002-6990-4441)
- Hui Zeng (ORCID: https://orcid.org/0000-0003-3943-1564)
- Mary Hobart
- Saloni Behl
Institutions
- Lundbeck (Denmark) (DK)
- University of Alabama at Birmingham (US)
- Otsuka (United States) (US)
- Otsuka Pharmaceutical (Spain) (ES)
Publication Details
- Journal
- Journal of Clinical Psychopharmacology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1097/jcp.0000000000002076
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00