Partial Response to Abatacept for Bilateral Asymmetrical Intermediate Uveitis in CTLA-4 Haploinsufficiency
CTLA-4 haploinsufficiency may present with asymmetrical intermediate uveitis and abatacept has a potential role in its treatment. Our case demonstrates the response to treatment through sequential multimodal imaging, and has the longest reported follow-up to date.
Authors
- Paul Torpiano (ORCID: https://orcid.org/0000-0002-6657-3579)
- Austen Worth (ORCID: https://orcid.org/0000-0001-6803-7385)
- Harry Petrushkin (ORCID: https://orcid.org/0000-0002-4662-2994)
- Ramzi Khalil (ORCID: https://orcid.org/0000-0001-7251-026X)
- Amit Patel (ORCID: https://orcid.org/0000-0001-5737-4319)
Institutions
- Moorfields Eye Hospital NHS Foundation Trust (GB)
- Great Ormond Street Hospital (GB)
- Gartnavel General Hospital (GB)
- Institute of Ophthalmology (MX)
- Moorfields Eye Hospital (GB)
- University College London (GB)
Publication Details
- Journal
- Ocular Immunology and Inflammation
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1080/09273948.2025.2504576
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00