Airway epithelial heterogeneity and mucus plugging in asthmatic bronchioles
Asthmatic bronchioles exhibit a T2-driven proximalization associated with mucus plugging. MUC5AC-high niches were identified heterogeneously in bronchiolar epithelia independent of immune cell localizations, suggesting asthmatic bronchioles contain cellular niches which perpetuate T2-initiated epithelial remodeling.
Authors
- Kenichi Okuda (ORCID: https://orcid.org/0000-0001-9341-2730)
- Richard C. Boucher (ORCID: https://orcid.org/0000-0002-5745-3989)
- Stephen A. Schworer (ORCID: https://orcid.org/0000-0001-7741-8972)
- Gabriela De la Cruz (ORCID: https://orcid.org/0000-0002-6019-5853)
- E.R. Strickler
- Gillian Crisp
- B. Cody
- Edwin A. Mitchell (ORCID: https://orcid.org/0000-0001-6187-7648)
- Z. Wiśniewski (ORCID: https://orcid.org/0000-0002-7069-7670)
- L. Morton
- Hong Dang (ORCID: https://orcid.org/0000-0002-7305-4208)
- Scott H. Randell (ORCID: https://orcid.org/0000-0001-5351-2841)
- Matthew R. Markovetz (ORCID: https://orcid.org/0000-0003-3931-0594)
- Takafumi Kato (ORCID: https://orcid.org/0000-0003-2248-3376)
- Wanda K. O’Neal (ORCID: https://orcid.org/0000-0003-2412-5943)
- Rodney C. Gilmore (ORCID: https://orcid.org/0000-0002-3821-8422)
- John B. Trudeau (ORCID: https://orcid.org/0000-0002-0473-2730)
- Frederic B. Askin (ORCID: https://orcid.org/0000-0002-4812-1704)
- Lauren M. Ralph
- Takanori Asakura (ORCID: https://orcid.org/0000-0003-3122-6937)
- Sally E. Wenzel (ORCID: https://orcid.org/0000-0002-4242-0164)
- Kevin M. Byrd (ORCID: https://orcid.org/0000-0002-5565-0524)
- Cynthia Koziol‐White (ORCID: https://orcid.org/0000-0003-1101-2747)
- Humberto E. Trejo Bittar (ORCID: https://orcid.org/0000-0003-2701-6531)
- Catharina van Heusden (ORCID: https://orcid.org/0009-0001-5403-5431)
- Alessandra Livraghi-Butrico (ORCID: https://orcid.org/0000-0001-8751-3631)
- Reynold A. Panettieri (ORCID: https://orcid.org/0000-0003-0834-4636)
- Hiroki Murano
- Gang Chen (ORCID: https://orcid.org/0000-0002-9989-2381)
- Minako Saito (ORCID: https://orcid.org/0000-0002-7369-167X)
- Michael Chua
- Kayleigh A. Doherty
- Shania Mastan
Institutions
- Rutgers, The State University of New Jersey (US)
- University of North Carolina at Chapel Hill (US)
- American Dental Association (US)
- University of Pittsburgh (US)
- Johnson University (US)
- UPMC Health System (US)
- Lung Institute (US)
- University of Pittsburgh Medical Center (US)
- Institut de Recherche et d’Innovation (FR)
Publication Details
- Journal
- American Journal of Respiratory and Critical Care Medicine
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1164/rccm.202409-1849oc
- Citations
- 2
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 3.04