Pharmacokinetics of (6S)-5-Methyltetrahydrofolate dicholine salt compared to folic acid: a randomized double-blind single dose cross-over study
The bioavailability of (6S)-5-MethylTHF-2Chol is higher compared to folic acid. The crystalline structure of (6S)-5-MethylTHF-2Chol and its water solubility are advantageous in terms of stability in nutraceutical products and absorption in the gut. (6S)-5-MethylTHF-2Chol is the source of folate that may enable the development of new applications.
Authors
- Manfred Wilhelm
- Daniel B. Menzel
- Antje Micka
- Rima Obeid (ORCID: https://orcid.org/0000-0002-0064-7029)
- Christiane Schön
Institutions
- BioTeSys (Germany) (DE)
- Technische Hochschule Ulm (DE)
- Saarland University (DE)
Publication Details
- Journal
- Food & Nutrition Research
- Published
- 2025-09-23
- DOI
- https://doi.org/10.29219/fnr.v69.12633
- Citations
- 1
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 1.67