CD3+ T cell depletion paradoxically worsens intracerebral hemorrhage through blood-brain barrier disruption
CD3+ T cell infiltration can aggravate brain injury related to cerebral hemorrhage, while extensive consumption of CD3+ T cells disrupts immune homeostasis and further exacerbates the injury. Precise regulation of T cell subsets rather than total depletion may be a key strategy for ICH immunotherapy.
Authors
- Yuming Hao
- Yingfu Zhang
- Yan Liang (ORCID: https://orcid.org/0000-0002-9502-101X)
- Chunying Zhu (ORCID: https://orcid.org/0000-0002-3520-8392)
- Huan Wang (ORCID: https://orcid.org/0000-0003-0794-9641)
- Tianci Zhang (ORCID: https://orcid.org/0000-0001-8239-8400)
- Xinjun Shan
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- Hebei University of Chinese Medicine (CN)
- Baoding People's Hospital (CN)
Publication Details
- Journal
- Neurological Research
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1080/01616412.2025.2559307
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00