Toll-like receptor 7/8 agonist stimulation rapidly skews the antibody repertoire of B cells in non-human primates
Our findings demonstrate that the TLR7/8 agonist rapidly induces a divergent expansion of B cells, establishing an immune foundation supporting vaccine responses and offering new insights into the dynamic B cell modulation.
Authors
- Michael Citron
- Shiyu Wang (ORCID: https://orcid.org/0000-0001-8851-1697)
- Xiao Liu (ORCID: https://orcid.org/0000-0002-8073-0534)
- Wei Zhang (ORCID: https://orcid.org/0000-0002-6968-6974)
- Lihua Luo (ORCID: https://orcid.org/0000-0002-2129-4226)
- I‐Ming Wang (ORCID: https://orcid.org/0000-0001-9414-0394)
Institutions
- BGI Group (China) (CN)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Central South University (CN)
- Xuzhou Medical College (CN)
- Pfizer (United States) (US)
- University Town of Shenzhen (CN)
- Tsinghua–Berkeley Shenzhen Institute (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1647209
- Citations
- 1
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.80