Auranofin Synergizes with Cisplatin in Reducing Tumor Burden of NOTCH-Dependent Ovarian Cancer
NOTCH signaling underlies cancer initiation, progression, and chemoresistance. Our study revealed the potential of auranofin as a NOTCH pathway inhibitor to enhance the efficacy of platinum-based ovarian cancer therapy.
Authors
- Robert J. Lake
- Kimberly Kay Leslie (ORCID: https://orcid.org/0000-0002-2704-8990)
- Hua-Ying Fan (ORCID: https://orcid.org/0000-0003-1790-4041)
- Parisa Nikeghbal (ORCID: https://orcid.org/0000-0002-6954-7544)
- Irina V. Lagutina (ORCID: https://orcid.org/0000-0001-9538-4008)
- Mara P. Steinkamp (ORCID: https://orcid.org/0000-0003-1226-9325)
Institutions
- University of New Mexico (US)
- New Mexico Cancer Center (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0190
- Citations
- 1
- Primary Topic
- Developmental Biology and Gene Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.81