Neuroprotective effects of bavachalcone in a mouse model of Parkinson’s disease: linking the gut-brain axis and systemic metabolism
Bavachalcone exerts neuroprotective effects in mice with PD by improving motor function, preserving dopaminergic neurons, reducing inflammation, modulating gut microbiota composition, and remodeling systemic metabolism. These findings highlight bavachalcone as a promising therapeutic candidate for PD.
Authors
- Mengyun Li (ORCID: https://orcid.org/0000-0001-8422-9061)
- Xueyan Bian (ORCID: https://orcid.org/0000-0001-8242-0292)
- Xiaobing Zhang (ORCID: https://orcid.org/0000-0003-1676-0138)
- Shuai Shi
- Wenpeng Huang (ORCID: https://orcid.org/0000-0001-7405-3816)
- Xuebin Yu
- Xian Shao (ORCID: https://orcid.org/0000-0002-4301-0255)
- Tiantian Lu
Institutions
- Shaoxing People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3389/fnins.2025.1650288
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39