“A STUDY OF EFFICACY AND SAFETY OF TABLET DEFLAZACORT IN PATIENTS WITH NASAL POLYPS ATTENDING A TERTIARY CARE HOSPITAL”

Objective: The aim of this study is to assess the efficacy and safety of the tablet deflazacort in nasal polyps patients and also to assess the causality, severity, and preventability of identified adverse drug reactions. Methods: Fifty patients with Nasal polyps were treated with Deflazacort. The efficacy of the drug was assessed by SNOT (Sino-nasal outcome test) SCORE at baseline (0), 1st, 2nd w. All the adverse drug reactions (ADRs) due to the study drug was reported in a Suspected Adverse Drug Reaction Reporting form in each follow-up. Results: After the completion of treatment, symptom scores of all the patients were improved. Of all the patients, 32% showed complete recovery, 50% showed improvement of symptoms, and 18% showed no/little improvement of symptoms. On an average about 82% of patients showed improvement in symptoms. Conclusion: The efficacy of Deflazacort in the treatment of Nasal polyps is proven in this study. Moreover, less Adverse drug reactions (ADRs) is also reported, which confers it as an optimal treatment choice for Diabetic patients who are requiring steroid therapy.