EVALUATION OF ANTIDEPRESSANT ACTIVITY OF AEGLEMARMELOS FRUIT EXTRACTS IN MICE

Objective: To evaluate Antidepressant Activity of Aqueous and Ethanolic extracts of Aeglemarmelos fruit in albino mice by using Forced swimming test (FST) and Tail suspension test (TST) parameters. Methods: For the study, 25–40 g healthy adult Swiss albino mice of both sexes will be housed in a conventional laboratory environment with a temperature of 25±2 °C, and a 12 h light–12 h dark cycle. Food and water will be offered ad libitum. The two antidepressant Animal model are used for asses the activity. A) Forced swimming test: This model requires the mice to swim or float for five minutes while submerged 40 cm in 23±1 °C of water in a glass cylinder. b) Tail suspension test in mice: In this model the mice are suspended at the edge of shelf approximately 58 cm above the tabletop by adhesive tape that is placed approximately 1 cm from the tip of the tail, and the duration of immobility is recorded for a 5 min duration. Results: In the present study, we have undertaken the antidepressant activity of ethanolic and aqueous extracts of Aeglemarmelos in Swiss albino mice, at the dose of 250 and 500 mg/kg, respectively, with oral administration respectively. Conclusion: In conclusion both the extracts ethanolic and aqueous extracts of Aeglemarmelos have shown significant results as an antidepressant effect using forced swim test (FST) and Tail Suspension test (TST) parameters.