A COMPREHENSIVE REVIEW ON APPLICATION OF HYALURONIC ACID IN DEVELOPMENT OF NOVEL DRUG DELIVERY SYSTEMS

Hyaluronic acid is a naturally present linear polysaccharide that contributes to various structural and physiological function in the human body. Its unique properties have led to its extensive exploration in various drug delivery system, including nasal, transdermal, parenteral, pulmonary, implantable, ocular, and gene delivery. HA chemical structural modification have enabled the development of diverse formulation, such as micelles, niosomes, liposomes, solid lipid nanoparticle, microsphere, and cyclodextrin which have shown promising results in enhancing drug bioavailability, targeting specific cells, and providing sustained release. HA mucoadhesive properties, ability to interact with specific receptor, and biocompatibility have made it an attractive biomolecule for pharmaceutical and medical advancements. This abstract highlighting the versatility and potential of HA in improving therapeutic efficacy and reducing side effect in various diseases condition.