THERAPEUTIC EVALUATION OF MICHELIA CHAMPACA ON NOISE-INDUCED HEPATORENAL ALTERATIONS IN RATS

Objective: The present study aimed to investigate the hepatoprotective and nephroprotective potential of Michelia champaca methanolic extract in male wistar rats subjected to noise-induced stress. Methods: Rats were exposed to noise stress at 100 dB for 4 h daily, for both acute (1 d) and chronic (30 d) durations. Liver function enzymes (AST, ALT, ALP), renal biomarkers (urea, creatinine), DNA fragmentation analysis, and histopathological evaluations were performed to assess organ damage and protective effects. Results: Chronic noise exposure led to a significant (p<0.05) increase in hepatic and renal biomarkers [AST, ALP, ALT, Creatinine, urea], indicating liver and kidney dysfunction. Additionally, DNA fragmentation revealed genotoxic stress in exposed animals. Administration of M. champaca extract (400 mg/kg body weight) markedly (p<0.05) attenuated these biochemical and molecular alterations in both acute and chronic exposure groups. Conclusion: The findings suggest that liver and kidney tissues are particularly vulnerable to noise-induced oxidative and genotoxic stress. Treatment with M. champaca extract conferred significant protective effects, likely due to its phytochemical constituents. Further studies are needed to elucidate its molecular mechanisms and potential clinical applications.