CD8+ T–NK cell crosstalk establishes preemptive immunosurveillance to eliminate antigen–escape tumors
Homeostatic conditioning and effector cooperativity between CD8<sup>+</sup>T and NK cells protect against tumor immune escape. The findings uncover a mechanistic axis of preemptive immunosurveillance that lays the foundation for next-generation preventive immunotherapies to control antigen-escape tumors.
Authors
- Tanu Rana (ORCID: https://orcid.org/0000-0002-4428-2754)
- Menaka C. Thounaojam (ORCID: https://orcid.org/0000-0002-3422-2053)
- Anil Shanker (ORCID: https://orcid.org/0000-0001-6372-3669)
- Anne‐Marie Schmitt‐Verhulst (ORCID: https://orcid.org/0000-0002-1296-2739)
- Lino Costa (ORCID: https://orcid.org/0000-0003-4772-4404)
- William Hofmeister (ORCID: https://orcid.org/0000-0002-4145-7061)
- Salvador González Ochoa (ORCID: https://orcid.org/0000-0002-5787-4759)
- Roman V. Uzhachenko (ORCID: https://orcid.org/0000-0002-5566-0810)
- Thanigaivelan Kanagasabai (ORCID: https://orcid.org/0000-0002-9867-8076)
- Alla V. Ivanova (ORCID: https://orcid.org/0000-0002-4149-5105)
- Harshana Rajakaruna
- J. Shawn Goodwin
- Maria Teresa P. de Aquino
- Thomas J. Sayers
- Alexander S. Terekhov
- Claude Boyer
Institutions
- Leidos (United States) (US)
- Meharry Medical College (US)
- Aerospace Testing Alliance (United States) (US)
- Frederick National Laboratory for Cancer Research (US)
- Centre d’Immunologie de Marseille-Luminy (FR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1593913
- Citations
- 2
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 2.09