Extended Survival in a Dog with Primary Bone Hemangiosarcoma Following Treatment with Neoadjuvant Oncolytic Virotherapy and Standard of Care

A three year old male neutered mixed breed dog presented with a mass on the right carpus and accompanying lameness. A Jamshidi bone biopsy was performed, and histopathology results were consistent with a sarcoma. The dog received oncolytic virotherapy (OV) with vesicular stomatitis virus (VSV) as part of a clinical trial in dogs with osteosarcoma (OSA). Ten days after VSV treatment, the affected limb was amputated, and histopathology was consistent with intramedullary HSA. Considering the new diagnosis, standard doxorubicin chemotherapy was prescribed. With this combination of therapies, the dog had an extended survival of more than seven years and remains alive at the time of writing. This is the first case report documenting OV given in conjunction with the standard of care for canine appendicular HSA.

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Publication Details

Journal
Veterinary Sciences
Published
2025-09-23
DOI
https://doi.org/10.3390/vetsci12100921
Primary Topic
Virus-based gene therapy research
Type
article
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Extended Survival in a Dog with Primary Bone Hemangiosarcoma Following Treatment with Neoadjuvant Oncolytic Virotherapy and Standard of Care

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Extended Survival in a Dog with Primary Bone Hemangiosarcoma Following Treatment with Neoadjuvant Oncolytic Virotherapy and Standard of Care

Davis Seelig, Christopher P. Ober, Jaime F. Modiano, Andrea Chehadeh, Michael S. Henson, Kathy Stuebner, Sara Pracht, Bishoy S. Eskander, Stephen J. Russell, Shruthi Naik, Mitzi Lewellen, Flaviu Tăbăran, Kelly M. Makielski, Maeve O’Sullivan, Courtney H. Labé, Amber L. Winter
article en

Abstract

A three year old male neutered mixed breed dog presented with a mass on the right carpus and accompanying lameness. A Jamshidi bone biopsy was performed, and histopathology results were consistent with a sarcoma. The dog received oncolytic virotherapy (OV) with vesicular stomatitis virus (VSV) as part of a clinical trial in dogs with osteosarcoma (OSA). Ten days after VSV treatment, the affected limb was amputated, and histopathology was consistent with intramedullary HSA. Considering the new diagnosis, standard doxorubicin chemotherapy was prescribed. With this combination of therapies, the dog had an extended survival of more than seven years and remains alive at the time of writing. This is the first case report documenting OV given in conjunction with the standard of care for canine appendicular HSA.

Veterinary SciencesVol. 12(10)
University of Minnesota (US), Mayo Clinic (US), University of Minnesota Rochester (US), University of Minnesota Medical Center (US)
Openalex Percentile: Top 72%
Virus-based gene therapy research
DOIOpen Access PDFOpenAlex
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