Curcumin protects against PIICS-induced liver injury by suppressing iron-induced lipid peroxidation: Insights from network pharmacology and experimental validation
CUR mitigates PIICS-induced liver injury by counteracting ferroptosis through modulation of lipid metabolism, iron homeostasis, and oxidative stress, offering a promising therapeutic strategy.
Authors
- Xiancheng Chen (ORCID: https://orcid.org/0000-0002-5837-1897)
- Yuanbo Xue
- Jianfeng Duan (ORCID: https://orcid.org/0000-0003-2701-2709)
- Ming Chen (ORCID: https://orcid.org/0000-0002-0683-2110)
- Wenkui Yu (ORCID: https://orcid.org/0000-0003-1298-8928)
- Jiawen Chen (ORCID: https://orcid.org/0000-0002-6022-9646)
- Gang Wang (ORCID: https://orcid.org/0000-0002-8407-6429)
- Jiali Liu (ORCID: https://orcid.org/0000-0002-2761-661X)
- Ximei Liang (ORCID: https://orcid.org/0000-0002-9025-6602)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1016/j.bbadis.2025.168053
- Citations
- 1
- Primary Topic
- Curcumin's Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.59