Cross‐Sectional <scp>FDG</scp> in Down Syndrome and Autosomal Dominant Alzheimer's Disease
Brain glucose metabolism is substantially lower for people with DS, even in individuals who are cognitively stable. The patterns of FDG decline are distinct in these 2 genetically determined forms of AD. The diagnostic utility of FDG-PET is specific to the genetic form of AD. ANN NEUROL 2025;98:1237-1248.
Authors
- Tammie L.S. Benzinger (ORCID: https://orcid.org/0000-0002-8114-0552)
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- Jee Hoon Roh (ORCID: https://orcid.org/0000-0002-3243-0529)
- James T. Kennedy
- Benjamin L. Handen (ORCID: https://orcid.org/0000-0001-9550-1665)
- Adam M. Brickman (ORCID: https://orcid.org/0000-0002-5125-8226)
- Manu S. Goyal (ORCID: https://orcid.org/0000-0003-1970-4270)
- Omar Abdelmoity (ORCID: https://orcid.org/0009-0003-8560-4339)
- Joseph Hyungwoo Lee (ORCID: https://orcid.org/0000-0002-2000-4821)
- Peter R. Schofield (ORCID: https://orcid.org/0000-0003-2967-9662)
- Christian la Fougère (ORCID: https://orcid.org/0000-0001-7519-0417)
- Michael S. Rafii (ORCID: https://orcid.org/0000-0003-2640-2094)
- Patrick J. Lao (ORCID: https://orcid.org/0000-0003-2243-3547)
- Andrei G. Vlassenko (ORCID: https://orcid.org/0000-0002-4776-4855)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- Takeshi Ikeuchi
- Julie K. Wisch (ORCID: https://orcid.org/0000-0003-3624-2784)
- Shahid Zaman (ORCID: https://orcid.org/0000-0003-1639-6014)
- H. Diana Rosas (ORCID: https://orcid.org/0000-0001-9360-7511)
- Sigan L. Hartley (ORCID: https://orcid.org/0000-0002-0186-6282)
- Gregory Scott Day (ORCID: https://orcid.org/0000-0001-5133-5538)
- Ricardo Allegri (ORCID: https://orcid.org/0000-0001-7166-1234)
- Florence Lai (ORCID: https://orcid.org/0000-0003-4354-0624)
- Elizabeth Head (ORCID: https://orcid.org/0000-0003-1115-6396)
- Sarah Keefe (ORCID: https://orcid.org/0000-0002-5943-0940)
- Beau M. Ances (ORCID: https://orcid.org/0000-0003-3862-7397)
- Shaney Flores (ORCID: https://orcid.org/0000-0003-2726-8704)
- David B. Keator (ORCID: https://orcid.org/0000-0001-5281-5576)
- Brian A. Gordon (ORCID: https://orcid.org/0000-0003-2109-2955)
- Jorge J. Llibre‐Guerra (ORCID: https://orcid.org/0000-0002-2137-7750)
- John C. Morris
Institutions
- University of Southern California (US)
- The University of Sydney (AU)
- University of Wisconsin–Madison (US)
- University of Pittsburgh (US)
- University of California, Irvine (US)
- Washington University in St. Louis (US)
- University of Cambridge (GB)
- Columbia University Irving Medical Center (US)
- Donald Danforth Plant Science Center (US)
- German Center for Neurodegenerative Diseases (DE)
- Jacksonville College (US)
- WinnMed (US)
- LMU Klinikum (DE)
- UNSW Sydney (AU)
- MaineGeneral Medical Center (US)
- Munich Cluster for Systems Neurology (DE)
- Cambridge Intellectual Property (United Kingdom) (GB)
- Instituto de Neurología Cognitiva (AR)
- München Klinik (DE)
- Hope Center for Neurological Disorders (US)
- Irvine University (US)
- Mayo Clinic in Florida (US)
- Korea University (JP)
- Niigata University (JP)
- Columbia University (US)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1002/ana.78002
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00