[Overemphasized surgical issues:the history, misconceptions, controversies, and future directions of lymph node detection thresholds and dissection range in colon cancer].
The number of lymph nodes detected in colon cancer is influenced by various factors. The arbitrary application of the 12-lymph node detection threshold as a quality control standard is unreasonable. Overemphasis on the number of lymph nodes may result in an unnecessarily extensive dissection, while existing evidence shows no survival benefit from routine D3 lymphadenectomy. This article systematically reviews the origin, rationale, influencing factors, and common misconceptions surrounding the lymph node detection threshold. It also looks ahead to the trend of narrowing the scope of lymphadenectomy in colon cancer and the potential for personalized dissection strategies.
Authors
- Aiwen Wu (ORCID: https://orcid.org/0000-0003-1877-7005)
- L Wang
- Y Y Gao
- Yi Xiao (ORCID: https://orcid.org/0000-0003-1788-4482)
- Junyang Lu (ORCID: https://orcid.org/0000-0003-0100-5535)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3760/cma.j.cn441530-20241205-00397
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00