Population pharmacokinetics of imipenem in solid tumor patients with infections: A real-world study
This study highlights the significant effect of specific pathophysiological changes in solid tumor patients (such as cachexia-induced reduction in volume of distribution) on drug disposition, providing essential evidence for informing personalized imipenem dosing in this vulnerable group to improve efficacy and reduce resistance risks.
Authors
- Tingting Zou (ORCID: https://orcid.org/0000-0002-7240-1378)
- Tingting Xu (ORCID: https://orcid.org/0000-0002-8353-9196)
- Zhiying Hao
- Junyan Zhang (ORCID: https://orcid.org/0000-0002-7890-3707)
- Zhuoran Li (ORCID: https://orcid.org/0000-0001-6192-4301)
- Fangyu Li (ORCID: https://orcid.org/0000-0003-4809-431X)
- Juan Du
Institutions
- University of Nottingham (GB)
- Shanxi Medical University (CN)
- Shanxi Provincial Cancer Hospital (CN)
- Cancer Hospital of Chinese Academy of Medical Sciences (CN)
Publication Details
- Journal
- Journal of Global Antimicrobial Resistance
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.jgar.2025.09.005
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00