Inhibitory effects against SARS-COV-2 main protease of terpenic substances and selenated naphthoquinones
Clinical studies on COVID-19 patients revealed among multiple symptoms, uncontrolled production of inflammatory mediators. The current study presents the inhibitory effects of eleven terpenoid derivatives (<b>1-11</b>) and two naphthoquinones (<b>12</b> and <b>13</b>) on the main protease (Mpro) of SARS-CoV-2. All the terpenoids and compound <b>13</b> displayed weak inhibitory effects while compound <b>12</b> showed moderate inhibitory effects of M<sup>pro</sup> with IC<sub>50</sub> of 50.2 µM. Anti-inflammatory effects against pro-inflammatory mediators produced in LPS-induced lung injury and the cytotoxicity against Vero and THP-1 cell lines of molecules <b>12</b> and <b>13</b> were also evaluated. Molecules <b>12</b> and <b>13</b> presented promising anti-inflammatory activity by attenuating the exudation and neutrophil and leukocyte migration.
Authors
- Gabriella B. Souza (ORCID: https://orcid.org/0000-0003-4117-531X)
- Tainá Larissa Lubschinski (ORCID: https://orcid.org/0000-0002-9938-2541)
- Francisco F. de Assis (ORCID: https://orcid.org/0000-0002-2042-8915)
- Bibiana Paula Dambrós (ORCID: https://orcid.org/0000-0003-2083-5008)
- Eduardo Monguilhott Dalmarco
- Antônio L. Braga (ORCID: https://orcid.org/0000-0001-9903-6764)
- Z Buss
- Tiago Tizziani (ORCID: https://orcid.org/0000-0002-2651-0557)
- Eufrânio N. da Silva Júnior (ORCID: https://orcid.org/0000-0003-1281-5453)
- Paula Giarola Fragoso de Oliveira (ORCID: https://orcid.org/0009-0009-4010-0843)
- Mário Steindel
- Marcos R. Scheide (ORCID: https://orcid.org/0000-0002-1133-9400)
- Louis P. Sandjo (ORCID: https://orcid.org/0000-0001-5840-7733)
- Bianca Klafke Beck
Institutions
- Universidade Federal de Minas Gerais (BR)
- Instituto Federal de Educação, Ciência e Tecnologia de Minas Gerais (BR)
- Universidade Federal da Paraíba (BR)
- Universidade Federal de Santa Catarina (BR)
- Exact Sciences (United States) (US)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-09-21
- DOI
- https://doi.org/10.1080/14786419.2025.2562591
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00