Kaempferol inhibits atherosclerotic plaque development via dual-targeting of p53-p21-p16 senescence pathway and Nrf2/HO-1/NQO1 antioxidant mechanism: Insights from combined in vivo and in vitro research
Kaempferol significantly ameliorates experimental atherosclerosis via simultaneous antioxidative and anti-senescent actions, highlighting its potential as a therapeutic agent for vascular disease.
Authors
- Ning Gu (ORCID: https://orcid.org/0000-0003-0704-6768)
- Weina Zhu (ORCID: https://orcid.org/0000-0001-9836-896X)
- Yajie Zhang (ORCID: https://orcid.org/0000-0003-2510-6015)
- Xinyi Cai (ORCID: https://orcid.org/0009-0002-5951-6733)
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.intimp.2025.115587
- Citations
- 1
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.80