Two novel 5,5-spiroketal sesquiterpenoid isomers from the roots of <i>Angelica biserrata</i> (R. H. Shan &Yuan) C. Q. Yuan & R. H. Shan
Two novel 5,5-spiroketal sesquiterpenoid isomers, duhuosesquid A (<b>1</b>) and duhuosesquid B (<b>2</b>) were isolated from the roots of <i>Angelica biserrata</i> (R. H. Shan & Yuan) C. Q. Yuan & R. H. Shan. Their structures were determined by extensive spectroscopic analyses, and the absolute configurations of <b>1</b> and <b>2</b> were assigned <i>via</i> NMR calculations and ECD calculations. Additionally, their anti-inflammatory activities were evaluated through <i>in vitro</i> assays, with IC<sub>50</sub> values of 15.9 ± 1.2 <i>μ</i>M and 14.2 ± 0.5 <i>μ</i>M, respectively.
Authors
- Fuyong Ni
- Xinmeng Jasmine Mu (ORCID: https://orcid.org/0000-0002-8079-0828)
- Ming Yan (ORCID: https://orcid.org/0000-0001-5116-8290)
- Xue Xie
- Z.‐F. XIE (ORCID: https://orcid.org/0009-0006-3263-4464)
- Rongrong Li (ORCID: https://orcid.org/0009-0001-7550-5869)
- Wei Xiao (ORCID: https://orcid.org/0000-0001-8809-9137)
- Zhenzhong Wang (ORCID: https://orcid.org/0000-0002-1364-3537)
- Ying Li (ORCID: https://orcid.org/0000-0002-5695-4706)
- Ningning Xu (ORCID: https://orcid.org/0000-0002-2988-5098)
- Chenfeng Zhang
Institutions
- Nanjing University of Chinese Medicine (CN)
- China Pharmaceutical University (CN)
- Kanion Pharmaceutical (China) (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-09-21
- DOI
- https://doi.org/10.1080/14786419.2025.2559770
- Primary Topic
- Sesquiterpenes and Asteraceae Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00