Volumetric Analysis of the Blood–Brain Barrier After Ischemic Stroke by Electron Tomography in Mice
Our toolkit allows for reproducible, high-resolution analysis of brain microvascular pathology. This new RT-ET approach uncovers previously inaccessible ultrastructural alterations in ECs following ischemic stroke in mice, offering new insight into mechanisms of BBB disruption.
Authors
- Baptiste Lacoste (ORCID: https://orcid.org/0000-0002-1922-8801)
- Pavel Kotchetkov (ORCID: https://orcid.org/0000-0003-2908-7755)
Institutions
- University of Ottawa (CA)
- Ottawa Hospital (CA)
- Ontario Brain Institute (CA)
- Ottawa Hospital Research Institute (CA)
- uOttawa Brain and Mind Research Institute
Publication Details
- Journal
- Microcirculation
- Published
- 2025-09-21
- DOI
- https://doi.org/10.1111/micc.70025
- Citations
- 1
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- University of Ottawa
- Canada First Research Excellence Fund
- Canadian Institutes of Health Research