Unraveling the Role of Perivascular Macrophages in Alzheimer's Disease: Insights from the Crosstalk between Immunometabolism and Ferroptosis
This study identifies eight key genes in PVMs that may protect against AD through mechanisms involving the interplay between immunometabolism and ferroptosis. Our findings provide novel insights into the function of PVMs in AD pathophysiology and suggest potential therapeutic targets for this devastating neurodegenerative disease.
Authors
- Anshi Wu (ORCID: https://orcid.org/0000-0003-2353-2184)
- Jinxu Wang
- Wei Yue (ORCID: https://orcid.org/0000-0002-7313-8516)
- Pengyi Li (ORCID: https://orcid.org/0000-0003-0092-2710)
- Minhao Zhang (ORCID: https://orcid.org/0000-0002-1334-4481)
- Jiahui Chen (ORCID: https://orcid.org/0000-0002-1458-1761)
- Qin Zhou (ORCID: https://orcid.org/0000-0002-2066-8169)
- Lei Qiu (ORCID: https://orcid.org/0000-0002-1080-1704)
- Xiaolei Miao
- Halisa Paerhati
Institutions
- Xuzhou Medical College (CN)
- Capital Medical University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Nanjing Maternity and Child Health Care Hospital (CN)
- Jiangsu Cancer Hospital (CN)
Publication Details
- Journal
- Current Neuropharmacology
- Published
- 2025-09-18
- DOI
- https://doi.org/10.2174/011570159x417328250908080404
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04