Long-Term Tumor Control After Carbon Ion Radiation Therapy Boost in Locally Advanced Cervical Clear Cell Adenocarcinoma

Clear cell adenocarcinoma of the uterine cervix is a rare and aggressive subtype of cervical cancer, typically resistant to conventional radiation therapy and lacking dedicated treatment guidelines. We present the case of a young patient with an ataxia telangiectasia mutation and locally advanced disease, who was unfit for brachytherapy following standard chemoradiotherapy and subsequently received a carbon ion radiation therapy boost. This mixed-beam strategy was well tolerated and led to durable local control along with a nodal response, which is suggestive of a possible abscopal effect. These findings underscore the potential of carbon ion radiation therapy in overcoming radioresistance and suggest a contributory role of genetic background in mediating systemic immune effects.

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Publication Details

Journal
International Journal of Particle Therapy
Published
2025-08-14
DOI
https://doi.org/10.1016/j.ijpt.2025.101200
Citations
1
Primary Topic
Radiomics and Machine Learning in Medical Imaging
Type
article
Field-Weighted Citation Impact
1.36
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article

Long-Term Tumor Control After Carbon Ion Radiation Therapy Boost in Locally Advanced Cervical Clear Cell Adenocarcinoma

Eloisa Arbustini, Carmine Tinelli, Marco Carnelli, Alessandro Vai et al.
1 citations
International Journal of Particle Therapy
Radiomics and Machine Learning in Medical Imaging
1.36
article

Long-Term Tumor Control After Carbon Ion Radiation Therapy Boost in Locally Advanced Cervical Clear Cell Adenocarcinoma

Eloisa Arbustini, Carmine Tinelli, Marco Carnelli, Alessandro Vai, Viviana Vitolo, Amelia Barcellini, Sara Imparato, Ester M. Orlandi, Carlo Pietro Soatti, D. Delishaj, E. Vitali
article en
1 citations

Abstract

Clear cell adenocarcinoma of the uterine cervix is a rare and aggressive subtype of cervical cancer, typically resistant to conventional radiation therapy and lacking dedicated treatment guidelines. We present the case of a young patient with an ataxia telangiectasia mutation and locally advanced disease, who was unfit for brachytherapy following standard chemoradiotherapy and subsequently received a carbon ion radiation therapy boost. This mixed-beam strategy was well tolerated and led to durable local control along with a nodal response, which is suggestive of a possible abscopal effect. These findings underscore the potential of carbon ion radiation therapy in overcoming radioresistance and suggest a contributory role of genetic background in mediating systemic immune effects.

International Journal of Particle TherapyVol. 17
University of Pavia (IT), National Center for Oncological Hadrontherapy (IT), Ospedale Papa Giovanni XXIII (IT), Alessandro Manzoni Hospital (IT), Policlinico San Matteo Fondazione (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Openalex Percentile: Top 16%
Radiomics and Machine Learning in Medical Imaging
1.36
DOIOpen Access PDFOpenAlex
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Long-Term Tumor Control After Carbon Ion Radiation Therapy Boost in Locally Advanced Cervical Clear Cell Adenocarcinoma — Eloisa Arbustini, Carmine Tinelli, et al. · International Journal of Particle Therapy (2025) | TGRS Research Map | TGRS