Social determinants of health, brain structure, and immune-metabolic mechanisms in depression: A multi-omic analysis from the UK Biobank
These findings underscore the multifaceted nature of depression, highlighting how social disadvantage becomes biologically embedded through genetic and physiological mechanisms. Addressing key modifiable components of SDH may represent a powerful strategy for targeted prevention, especially in genetically at-risk populations.
Authors
- Huajia Tang
- Zheng Chang (ORCID: https://orcid.org/0000-0002-8087-1417)
- Jing Gu (ORCID: https://orcid.org/0000-0001-5436-2339)
- Sihong Li (ORCID: https://orcid.org/0000-0002-4482-2423)
- Huijie Xu
- Yanyue Ye
- Zhengqian Jiang
- Zheng Zhang (ORCID: https://orcid.org/0000-0002-0389-1844)
- Hui Chen (ORCID: https://orcid.org/0009-0007-4801-9762)
- Jiansong Zhou (ORCID: https://orcid.org/0000-0002-4410-4202)
- Bohao Cheng
Institutions
- Central South University (CN)
- Karolinska Institutet (SE)
- National Clinical Research (US)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1016/j.bbi.2025.106117
- Citations
- 5
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.89