<scp>MarkVCID2</scp> Consortium for Clinical Validation of Biomarkers of Cerebral Small Vessel Disease: Validation Framework and Baseline Characteristics
MarkVCID2 baseline data indicate successful enrollment of diverse individuals enriched in factors associated with SVD-related cognitive decline. Changes over 3 years of longitudinal follow-up will be analyzed to validate the candidate biomarkers for 2 projected contexts of use: subject selection (identifying likelihood of future SVD progression) and study outcome (efficiently measuring SVD progression). ANN NEUROL 2026;99:449-458.
Authors
- Bruce M. Psaty (ORCID: https://orcid.org/0000-0002-7278-2190)
- Christian Lachner (ORCID: https://orcid.org/0000-0002-1801-9768)
- Deborah Blacker (ORCID: https://orcid.org/0000-0001-6107-7376)
- Gregory A. Jicha (ORCID: https://orcid.org/0000-0002-7980-2166)
- Hillary Mulder (ORCID: https://orcid.org/0000-0003-4838-582X)
- Donna M. Wilcock (ORCID: https://orcid.org/0000-0003-3388-1564)
- Andria L. Ford (ORCID: https://orcid.org/0000-0003-0605-8943)
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Jin‐Moo Lee (ORCID: https://orcid.org/0000-0002-3979-0906)
- Hanzhang Lu (ORCID: https://orcid.org/0000-0003-3871-1564)
- Joel H. Kramer (ORCID: https://orcid.org/0000-0002-2917-8297)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0003-0756-5007)
- Peiying Liu (ORCID: https://orcid.org/0000-0003-0830-5960)
- Arvind Caprihan (ORCID: https://orcid.org/0000-0002-4810-359X)
- Sue Moy
- Sean I. Savitz (ORCID: https://orcid.org/0000-0003-4637-1790)
- Lisa Wruck (ORCID: https://orcid.org/0000-0003-1732-9067)
- Lidiya Mazina
- Prashanthi Vemuri (ORCID: https://orcid.org/0000-0003-4286-0589)
- Ronald Carl Petersen (ORCID: https://orcid.org/0000-0002-8178-6601)
- Hongyu An (ORCID: https://orcid.org/0000-0001-6459-2269)
- Konstantinos Arfanakis (ORCID: https://orcid.org/0000-0001-9705-597X)
- Pauline Maillard (ORCID: https://orcid.org/0000-0003-3516-6345)
- Arnold M Evia (ORCID: https://orcid.org/0000-0003-2262-890X)
- B. Gwen Windham
- Gary A. Rosenberg (ORCID: https://orcid.org/0000-0001-7426-7064)
- Courtney Page (ORCID: https://orcid.org/0000-0001-7671-3355)
- Carissa Tuozzo (ORCID: https://orcid.org/0000-0003-0946-076X)
- Kristin Schwab (ORCID: https://orcid.org/0000-0001-5723-9109)
- Gregory Scott Day (ORCID: https://orcid.org/0000-0001-5133-5538)
- Steven Mark Greenberg (ORCID: https://orcid.org/0000-0003-1792-8887)
- Roderick A. Corriveau (ORCID: https://orcid.org/0000-0002-6954-9240)
- Danny J.J. Wang (ORCID: https://orcid.org/0000-0002-0840-7062)
- Jason D. Hinman (ORCID: https://orcid.org/0000-0002-0872-5044)
- Herpreet Singh (ORCID: https://orcid.org/0000-0003-3797-7301)
- Pia Kivisäkk (ORCID: https://orcid.org/0000-0001-9708-7509)
- Amir H. Kashani (ORCID: https://orcid.org/0000-0001-9767-7920)
- John M. Ringman (ORCID: https://orcid.org/0000-0001-5429-0777)
- Marylin S. Albert
- Karl G. Helmer (ORCID: https://orcid.org/0000-0002-5113-6843)
- Rong Zhang (ORCID: https://orcid.org/0000-0002-6534-5216)
- Myriam Fornage (ORCID: https://orcid.org/0000-0003-0677-8158)
- Claudia Liliana Satizábal (ORCID: https://orcid.org/0000-0002-1115-4430)
- Vilma Okey‐Ewurum (ORCID: https://orcid.org/0000-0002-9001-4945)
Institutions
- University of Southern California (US)
- University of Maryland, Baltimore (US)
- Rush University Medical Center (US)
- Kennedy Krieger Institute (US)
- Mind Research Network (US)
- Harvard University (US)
- University of Kentucky (US)
- Johns Hopkins University (US)
- University of California, Los Angeles (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of New Mexico (US)
- Duke University (US)
- University of California, San Francisco (US)
- Illinois Institute of Technology (US)
- Neurosciences Institute (US)
- Washington University in St. Louis (US)
- Johns Hopkins Medicine (US)
- Jacksonville College (US)
- WinnMed (US)
- University of Mississippi Medical Center (US)
- Massachusetts General Hospital (US)
- Clinical Research Institute (US)
- Southwestern Medical Center (US)
- Mallinckrodt (United States) (US)
- National Institute of Neurological Disorders and Stroke (US)
- Baim Institute for Clinical Research (US)
- Institute for Neurodegenerative Disorders (US)
- Department of Health (TW)
- Mayo Clinic in Arizona (US)
- Brown Foundation (US)
- Mayo Clinic in Florida (US)
- The University of Texas Health Science Center (US)
- Southwestern Medical Center (US)
- Indiana University – Purdue University Indianapolis (US)
- University of California, Davis (US)
- The University of Texas Southwestern Medical Center (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1002/ana.78040
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 4.41