A pharmacometric model assessing the in vitro synergistic effect of a bacteriophage-polymyxin B combination in a clinical multidrug-resistant Klebsiella pneumoniae isolate
The study shows that phage pK8 and polymyxin B combination effectively combats a clinical polymyxin-resistant K. pneumoniae strain. These promising results pave the way for further in vivo studies to validate and refine treatment strategies for tackling multidrug-resistant infections.
Authors
- Sue C. Nang (ORCID: https://orcid.org/0000-0003-0397-820X)
- Heidi H. Yu
- Hasini Wickremasinghe
- Aneeq Farooq
- Sebastian G. Wicha (ORCID: https://orcid.org/0000-0002-8773-4845)
- Jian Li (ORCID: https://orcid.org/0000-0001-7953-8230)
- Yu-Wei Lin (ORCID: https://orcid.org/0000-0001-7316-5293)
- Mei-Ling Han
Institutions
- Universität Hamburg (DE)
- Discovery Institute (US)
- Australian Regenerative Medicine Institute (AU)
- Monash University (AU)
Publication Details
- Journal
- International Journal of Antimicrobial Agents
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1016/j.ijantimicag.2025.107628
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59