Long-term Immunogenicity of Hepatitis A Vaccination in Adults Receiving Immunosuppressive Therapy and Adults Living With HIV: Three-year Follow-up of a Prospective Cohort Study
Three years postvaccination, most ICPs remained seroprotected, but SPRs and GMCs were lower than in healthy controls, particularly in patients on combination immunosuppressive therapy. However, it remains uncertain if booster doses are necessary among those who seroreverted, as long-term protection may persist through formed cellular memory.
Authors
- Agnes M. Harskamp
- Irma Maurer (ORCID: https://orcid.org/0000-0003-2864-2139)
- Hannah M Garcia Garrido (ORCID: https://orcid.org/0000-0002-8481-5455)
- Jenny L Schnyder (ORCID: https://orcid.org/0000-0002-2691-8130)
- Abraham Goorhuis (ORCID: https://orcid.org/0000-0001-7423-6217)
- Neeltje A. Kootstra (ORCID: https://orcid.org/0000-0001-9429-7754)
- Martin P. Grobusch (ORCID: https://orcid.org/0000-0002-0046-1099)
Institutions
- Amsterdam Neuroscience (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1093/ofid/ofaf457
- Primary Topic
- Hepatitis Viruses Studies and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00