Scoping review of the effects of antihistamines on physiological responses to alcohol among individuals with natural and induced alcohol flushing reactions

Antihistamines may attenuate alcohol skin flushing in alcohol-sensitive individuals with mixed and inconclusive effects on other physiological responses. Current evidence is limited by small sample sizes, inconsistent findings, and a lack of acetaldehyde measurement. These limitations highlight the urgent need for rigorous studies to clarify the health risks of alcohol-antihistamine co-use and to inform harm reduction strategies for vulnerable populations. Understanding these interactions is vital for public health to inform targeted education and interventions.