Amphiregulin reflects brain metastasis progression and leads to PD-L1 expression in non-small cell lung cancer cells
AREG supports tumor adaptation to mechanical stress and may drive immune tolerance via PD-L1. Its correlation with BM burden highlights its potential as a biomarker and therapeutic target in NSCLC.
Authors
- Elodie A. Pérès (ORCID: https://orcid.org/0000-0002-6687-1939)
- J. Madelaine
- Dimitri Leite Ferreira
- Tiphaine Biojout
- Laureline Charrier
- Jérôme Toutain (ORCID: https://orcid.org/0000-0001-9031-0907)
- Jérôme Levallet (ORCID: https://orcid.org/0000-0003-4133-2813)
- Samuel Valable (ORCID: https://orcid.org/0000-0003-0355-0270)
- Céline Bazille (ORCID: https://orcid.org/0000-0003-0289-6720)
- Guénaëlle Levallet (ORCID: https://orcid.org/0000-0001-7772-0581)
- M. Guyot
- Emmanuel Bergot (ORCID: https://orcid.org/0000-0002-8097-8820)
- Lucie Malandain
Institutions
- Centre National de la Recherche Scientifique (FR)
- Normandie Université (FR)
- Centre Hospitalier Universitaire de Caen Normandie (FR)
- Centre Hospitalier Universitaire de Rouen (FR)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1016/j.biopha.2025.118600
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00