Two new gingerol derivatives from the rhizome of <i>Curcuma xanthorrhiza</i> D.Dietr
A phytochemical investigation of the EtOAc-soluble extract from the rhizomes of <i>Curcuma xanthorrhiza</i> D.Dietr. led to the isolation of five gingerol derivatives, including two news, xanthorrhiza A (<b>3</b>) and xanthorrhiza B (<b>5</b>). These compounds were purified through column chromatography, and their structures were elucidated through spectral analysis. Bioactivity testing revealed that xanthorrhiza B (<b>5</b>) exhibited the strongest tyrosinase inhibitory activity with an IC<sub>50</sub> value of 61.0 μM, as strong as a positive control, kojic acid (IC<sub>50</sub>: 44.6 µM). Additionally, the <i>α</i>-glucosidase inhibitory activity of 8-dehydrogingerdione (<b>2</b>) was the most potent than that of evaluated compounds, with an IC<sub>50</sub> value of 19.5 μM, and more potent than a positive control, acarbose (IC<sub>50</sub>: 185.2 μM).
Authors
- Truong Nhat Van Do (ORCID: https://orcid.org/0000-0001-8538-7539)
- Tho Huu Le (ORCID: https://orcid.org/0000-0001-9623-2858)
- Minh Nguyen (ORCID: https://orcid.org/0009-0004-8020-9767)
- Hai Xuan Nguyen (ORCID: https://orcid.org/0000-0001-8447-8367)
- Thang Truong (ORCID: https://orcid.org/0000-0002-2165-6872)
- Nhan Trung Nguyen (ORCID: https://orcid.org/0000-0001-5142-4573)
- Mai Thanh Thi Nguyen (ORCID: https://orcid.org/0000-0001-8006-4028)
- Dieu Hien Truong
Institutions
- Vietnam National University Ho Chi Minh City (VN)
- Ho Chi Minh City University of Science (VN)
- Drug Discovery Laboratory (Norway) (NO)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-09-21
- DOI
- https://doi.org/10.1080/14786419.2025.2562597
- Primary Topic
- Ginger and Zingiberaceae research
- Type
- article
- Field-Weighted Citation Impact
- 0.00