SMC4 promotes immune evasion by inhibiting endogenous interferon signaling and upregulating PD-L1 expression in triple negative breast cancer
Our findings establish SMC4 as a dual regulator of immune evasion in TNBC and propose targeting SMC4 as a promising combinatorial strategy to overcome the current limitations in immunotherapy.
Authors
- Jiayu Zhu (ORCID: https://orcid.org/0000-0002-0793-6579)
- Hui Xue (ORCID: https://orcid.org/0000-0002-7970-8647)
- Lei Zhang (ORCID: https://orcid.org/0009-0007-9339-3331)
- Qingyuan Zhang (ORCID: https://orcid.org/0000-0001-7618-4393)
- Lingmin Shang
- Jianli Ma (ORCID: https://orcid.org/0009-0008-0362-7075)
Institutions
- Harbin Medical University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.intimp.2025.115580
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09