Characterization of hypoxia-related molecular clusters and prognostic riskScore for glioma

Ultimately, we identified four core hub genes-SOCS3, CLCF1, PLAUR, and LIF-whose expression was validated under hypoxic conditions via Western blot analysis in glioma cell lines. This study employs bioinformatics to elucidate glioma subtypes, highlighting significant prognostic and functional disparities. The experimental validation of candidate molecules paves the way for future research aimed at unraveling their roles and underlying mechanisms in glioma pathophysiology, potentially guiding novel therapeutic strategies.