Association between genetic mutations in lung adenocarcinoma and adult body mass index: a retrospective cohort study

This study reveals a significant association between BMI and ADC gene mutations, demonstrating that elevated BMI levels correlate negatively with mutation risk within the specific range of 21.08 to 22.86 kg/m². Furthermore, the rate of gene mutation may be relatively high in women under the age of 60 who do not smoke or drink. This study may assist clinicians in preliminarily assessing the gene mutation status of patients with ADC.

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Publication Details

Journal
Frontiers in Oncology
Published
2025-09-22
DOI
https://doi.org/10.3389/fonc.2025.1661143
Primary Topic
Lung Cancer Treatments and Mutations
Type
article
Field-Weighted Citation Impact
0.00

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article

Association between genetic mutations in lung adenocarcinoma and adult body mass index: a retrospective cohort study

Yan Wu, Depeng Jiang, Lei Yang
Frontiers in Oncology
Lung Cancer Treatments and Mutations
article

Association between genetic mutations in lung adenocarcinoma and adult body mass index: a retrospective cohort study

Yan Wu, Depeng Jiang, Lei Yang
article en

Abstract

This study reveals a significant association between BMI and ADC gene mutations, demonstrating that elevated BMI levels correlate negatively with mutation risk within the specific range of 21.08 to 22.86 kg/m². Furthermore, the rate of gene mutation may be relatively high in women under the age of 60 who do not smoke or drink. This study may assist clinicians in preliminarily assessing the gene mutation status of patients with ADC.

Frontiers in OncologyVol. 15
Dalian Medical University (CN), Second Affiliated Hospital of Chongqing Medical University (CN), Chongqing Medical University (CN)
Chongqing Medical University
Openalex Percentile: Top 63%
Lung Cancer Treatments and Mutations
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