Preparation and Evaluation of Sodium Alginate Nanoparticles Containing Recombinant Diphtheria Toxoid (CRM197) and their Immunogenicity in Mice
Engineered alginate nanoparticles loaded with recombinant diphtheria antigen (CRM197) demonstrated in vitro controlled and slow release, as well as safety and immunogenicity profiles against diphtheria in vivo. Nanoparticles containing CRM197 antigens equivalent to adult and children doses showed high levels of IgG1 and IgG2a, confirming the combined responses of the humoral and cellular immune systems.
Authors
- Parvaneh Saffarian (ORCID: https://orcid.org/0000-0002-2932-600X)
- Zahra Salehi-Najafabadi (ORCID: https://orcid.org/0000-0002-0658-9966)
- Hamid Reza Goudarzi (ORCID: https://orcid.org/0000-0001-9535-6226)
- Samira Aghamiri (ORCID: https://orcid.org/0000-0003-1965-4357)
- Mojtaba Noofeli (ORCID: https://orcid.org/0000-0003-4991-4631)
Institutions
- Razi Vaccine and Serum Research Institute (IR)
- Islamic Azad University South Tehran Branch (IR)
- Agricultural Research & Education Organization (IR)
Publication Details
- Journal
- Current Pharmaceutical Design
- Published
- 2025-09-18
- DOI
- https://doi.org/10.2174/0113816128402345250905072744
- Primary Topic
- Toxin Mechanisms and Immunotoxins
- Type
- article
- Field-Weighted Citation Impact
- 0.00